Using Bayesian modeling in frequentist adaptive enrichment designs
نویسندگان
چکیده
منابع مشابه
Optimized adaptive enrichment designs.
Based on a Bayesian decision theoretic approach, we optimize frequentist single- and adaptive two-stage trial designs for the development of targeted therapies, where in addition to an overall population, a pre-defined subgroup is investigated. In such settings, the losses and gains of decisions can be quantified by utility functions that account for the preferences of different stakeholders. I...
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ژورنال
عنوان ژورنال: Biostatistics
سال: 2017
ISSN: 1465-4644,1468-4357
DOI: 10.1093/biostatistics/kxw054